Background and aim: Given the increased of prevalence and be used to beginning of Cigarette and other drug in high school students, and the role of knowledge and attitude of people on their behaviors, this research is performed with the aim of studying The effect of education about prevention of addiction through health belief model (HBM) on knowledge and perceptions of high school students in Saveh. Materials and methods: This quasi experimental study that was before and after test, from ten high schools, 387 students selected through application of randomized cluster sampling methods. Health Belief Model used in education. Subjects are evaluated in two stages primary test before application of educational program, and secondary test after educational program implemented by questionnaire which included the identification, knowledge and attitude questions. The statistical analysis carried on paired t-test, χ Square, ANOVA and Pearson correlation co-efficient. Results: Comparisons of between mean of knowledge, attitude scores of students indicated significance deference before and after educational program implemented (P<0.0001).There was positive correlation between knowledge and total perceptions scores before and after education (r=.31, r= .37, p<.0001). There were significant relationships between knowledge and parents’ literacy (p<.01, p<.02), fathers’ job (p<.01) and kind of high school (p<.0001. Also there were significant differences between perceived barriers and mothers’ literacy (P<.02), family history of addiction (p<.01) and between perceived benefits and kind of high school (p<.01) and between perceived sensitivity (P< .04) and between perceived sever and kind of high school (p<.02). Conclusion: health education through health belief model with the aim drug abuse prevention have a positive effect on knowledge, perceptions of people, and in primary prevention of drug abuse, it is a cost-efficient strategy. This study is considered as beginning of a more research this area.